We invite you to join our interdisciplinary international team and develop breakthrough approaches to predict long-term health hazards of materials. You will contribute to the discovery and understanding of the early mechanisms through which nanomaterials trigger long-lasting health effects by combining cutting-edge live-cell microscopy, biophysics, biology and computer modelling. We will support you in applying your basic scientific research to develop new tools for fast and cost-efficient safety assessment, which will be efficiently passed into real-life settings through our ties to regulators and industrial partners to protect workers and consumers.

If you have a strong research interest in the bio-fields, an open mind to challenge the dogmas, and if you enjoy teamwork and working on projects of varying sizes, we encourage you to apply. Experience in bio-imaging, optics, image analysis, wet lab work and programming is highly welcome.

Candidates should submit a personally written motivation letter (max 1 page), a structured CV, a comprehensive list of publications, and at least two references. Applications should be sent to Janez Štrancar (janez.strancar@ijs.si) and Iztok Urbančič (iztok.urbancic@ijs.si) with the subject line “Postdoc position” or directly via the apply button.

The call is open for applications until 15th December 2024, early submissions may accelerate the interview process.

We have a funded 4-year PhD studentship starting in Sept 2025. This will use the new "Multiscope" parallelised microscope to study the effect of neuroendocrine signalling on feeding behaviour. Answer fundamental bioscience questions using high throughput imaging. Please get in touch!

Pictura Bio is seeking a skilled Prototype Engineer for a short-term project focused on developing a smartphone-enabled fluorescence microscopy system for imaging pathogens. The project entails building and refining a compact, smartphone-compatible imaging setup. The ideal candidate will have a strong background in optics and fluorescence microscopy, with hands-on experience adapting optical systems for smartphone integration. Requirements:

1. Deep expertise in optics and fluorescence microscopy.
2. Proven experience in designing and prototyping smartphone-compatible imaging systems.
3. Strong ability to work independently and troubleshoot technical challenges.
4. Availability for a short-term, hands-on project. How to Apply: Please contact nicolas.shiaelis@pictura.bio.

Dive into pioneering research at the intersection of microbiota and cancer as a Postdoctoral Researcher at LUMC. You’ll explore how microbial communities shape tumor development and mine data from novel spatial omics approaches to gain insights into microbes-host interactions at the cellular and molecular level. Collaborate with leading international experts while benefiting from cutting-edge research facilities. Your top-3 tasks are:

• Contribute to the design of novel multiplex FISH technologies by designing barcoding schemes, probes and decoding approaches.
• Develop and apply computational tools for bioimage analysis, including image registration, cell segmentation, and the delineation of molecular niches in tumor tissues.
• Integrate and analyze data from diverse spatial and bulk omics platforms, which together capture rich molecular information of both the microbiome and the host, to delineate microbe-host cross-talk of relevance for tumorigenesis and inflammation.

The Bio-Imaging Resource Center (BIRC) at the Rockefeller University in New York City is seeking a motivated full-time microscopist to advise and train users on our commercial microscopes and to push these systems to new levels! In addition, the applicant will liaise with the image analysts in the BIRC and also with our optical engineer, who is building pre-commercial light sheet systems in our satellite laboratory.

Post-doctoral researcher for laboratory of Eliisa Kekäläinen, where the project's main research target is the human thymus and how it protects itself during hematopoietic stem cell transplantation. The project utilizes IBEX imaging technology to unravel the microanatomical changes in the thymus during ageing. The project also aims to develop an in vitro organ culture model for the human thymus where different external insults and their effect on the thymic microanatomy can be tested. This project has received the highly competitive ERC Starter funding for 5 years.

Summary: The Ragon Institute is a highly unique, innovative, and collaborative research center at the forefront of biomedical science. Founded by Massachusetts General Hospital, MIT, and Harvard, the Ragon vision is a bold one: to harness the power of the immune system to prevent and cure human disease on a global scale. This vision is pursued and advanced every day by a group of highly motivated individuals. The Ragon Institute, at every level, depends upon collaboration, compassion, dedication, and innovation.  It is a results-oriented organization that seeks people who not only embrace these values but who thrive in teams and want to work in a dynamic environment.

At the Ragon Institute, people are our greatest asset.  In this role, the Microscopy Director will be an integral part of the evolution of the organization.  They will be responsible for overseeing the daily operations and financial solvency of the Ragon’s current microscopy core, but they will also play a critical role in helping to evolve and grow the facility.  Specifically, the Microscopy Director will manage state-of-the-art fluorescence microscopy equipment s, supporting a wide range of scientific research across multiple disciplines, including immunology, tissue biology, cell biology, and microbiology. The Director will also be responsible for ensuring the microscopy facility operates at the highest standards, providing technical expertise, training, and support to researchers, and driving innovation in imaging techniques and technologies.

The ideal candidate is a highly skilled scientist with deep expertise in advanced microscopy techniques, a proven track record of supporting cutting-edge research, enjoy collaborating with multi-disciplinary teams, thrive on creating new processes, and possess strong leadership and management abilities.  Ultimately, they will be a strategic thought partner and a trusted advisor to the core users and Ragon leadership team. Primary Duties and Responsibilities: Leadership and Oversight:

• In collaboration with end-users, develop and implement a strategic plan for the facility, ensuring that it stays at the forefront of microscopy technology and research capabilities.
• Compare the core to peer institutions’ resources through benchmarking studies.
• Identify appropriate facility operating metrics and regularly analyze data.
• Develop a process to track core utilization and optimization.
• Present programmatic and financial data analysis on core performance to a variety of audiences.
• Advise the Executive Team and Faculty regarding the scientific appropriateness and value of current / new equipment for the core.
• Ensure compliance with MGH, Ragon, and US Federal regulations as they apply to core facilities. Facility Management and Operations:
• Lead and manage all microscopy operations, ensuring the smooth functioning and availability of instruments, technology platforms, and services to researchers.
• Determines and writes user policies for the facility.
• Stay updated on the latest microscopy advancements and disseminate best practices across the research community.
• Develop educational programs, workshops, and seminars to enhance the knowledge and skills of microscopy users within the organization.
• Lead the training and mentorship of scientists, students, and staff in microscopy techniques, image acquisition, and analysis. Research Support and Collaboration:
• Work closely with researchers across various scientific disciplines to design and optimize microscopy experiments, providing guidance on the best imaging techniques, protocols, and analyses for their scientific questions.
• Collaborate with investigators to develop novel imaging approaches and methods, facilitating high-impact publications and discoveries.
• Act as a liaison between the microscopy core and research groups, ensuring that services are aligned with the evolving needs of the scientific community. Financial Oversight
• Collaborate with the Ragon Finance Team and Imaging Committee in creating long and short-term business plans and yearly budgets.
• Monitor budgets to ensure fiscal solvency.
• Report on core performance; investigate and provide resolution options to remedy variances from expected to actual business and performance indicators.
• Maintain accurate records of facility usage for reporting and billing purposes.
• Oversee safety protocols and ensure compliance with all relevant regulations regarding the use of microscopes and related technologies. Equipment Management and Innovation:
• Oversee the maintenance, calibration, and upgrades of all microscopy equipment, ensuring optimal performance and data quality.
• Drive innovation by introducing new microscopy technologies, imaging modalities, and advanced techniques such as high-resolution multiplexed confocal imaging (both in tissues and cells), cleared 3D organ imaging, multiphoton imaging, spatial omics, FLIM, and live-cell imaging.
• Collaborate with vendors and suppliers to evaluate and acquire new instruments that enhance the facility’s capabilities.
• Advise the space committee around the physical space requirements for institutional shared research cores. Data Management and Analysis:
• Oversee data acquisition, processing, and image analysis workflows, ensuring that high-quality imaging data is collected and stored appropriately.
• Implement and provide support for advanced image analysis software and tools (e.g., Imaris, Avia, Arivis, Napari, ImageJ etc.), ensuring that researchers can effectively analyze complex datasets.
• Promote the integration of microscopy data with other scientific datasets to support multi-modal analysis and advanced research. Grant Writing and Funding:
• Support researchers in the preparation of grant applications by providing technical expertise related to microscopy techniques and experimental design.
• Lead and contribute to the development of facility-based grants to enhance the microscopy core’s capabilities and support infrastructure improvements.     Education:
• PhD in biology, biophysics, biomedical engineering, or a related field with significant experience in advanced microscopy techniques.

Experience:

• 7+ years of experience in fluorescence microscopy, including but not limited to confocal, live-cell  light sheet, multiphoton, and super-resolution microscopy, with a strong record of publications or research contributions. Experience with modern multiplexed tissue/organ imaging techniques is highly advantageous.
• Ideally, extensive experience in managing or directing a microscopy core facility or research laboratory.
• Proven ability to collaborate with and support researchers in designing microscopy experiments across diverse scientific disciplines.
• Prior experience in an academic setting highly preferred.

Skills:

• Deep expertise in advanced microscopy techniques and imaging modalities.
• Proficient in microscopy software and image analysis tools (e.g., ImageJ, Imaris, or similar).
• Strong leadership and management skills, with experience in supervising staff and training users.
• Excellent communication and interpersonal skills to interact with a broad range of researchers and stakeholders.
• Ability to troubleshoot complex technical issues and optimize imaging protocols for scientific rigor.

Preferred Qualifications:

• Significant experience with light and fluorescence microscopy, including live-cell confocal, super-resolution, light sheet and other  and specialized imaging techniques.
• Experience in quantitative image analysis. A familiarity with modern machine learning and artificial intelligence applications in image analysis is a benefit.
• Experience with grant writing and securing funding for microscopy-related research or infrastructure.

Work Setting: M-F, 8:30 am – 5 pm, on-site

The above job description details the major duties and qualifications of the listed position. The individual hired to this position confirms that they are able to perform all duties outlined. Although the specific duties and responsibilities of this position may vary slightly, the supervisor of this position will ensure that the individual hired to this position is trained and qualified to complete each task assigned.    EEO Statement   Massachusetts General Hospital is an Affirmative Action Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.    Primary Location MA-Cambridge-MGH Ragon Institute Work Locations MGH Ragon Institute 600 Main St  Cambridge 02139 Job Research - Other Organization Massachusetts General Hospital(MGH) Schedule Full-time Standard Hours 40 Shift Day Job Employee Status Regular Recruiting Department Ragon Institute Job Posting Oct 11, 2024

Project title Analysis of the dynamics of DNA repair proteins using single molecule tracking in living cells.

Job description One research engineer position is available in the group of Sébastien Huet for a period of 2 years starting early 2025. The team belongs to the Institut de Génétique et du Développement de Rennes (http://igdr.univ-rennes1.fr/). It is currently composed of seven people with complementary expertise (molecular and cellular biology, biophysics, fluorescence imaging, mathematical modeling). The team is interested in the analysis of the early steps of the DNA repair mechanisms, focusing on the behavior of the two first responders PARP1 and OGG1 which detect single-strand breaks or 8-oxoguanine, respectively. Using advanced live-cell imaging approaches, the team investigates the target-search mechanisms used by these two factors to efficiently find their cognate lesions along the genome and characterizes their dynamic association with these lesions. The recruited engineer will be involved in the development of single-molecule imaging approaches to track individual fluorescently tagged PARP1 and OGG1 in living cells. These developments will be performed in close collaboration with the lab of Ignacio Izeddin from the Institut Langevin in Paris.

Qualifications The applicant should hold a PhD in biophysics or cell biology. A proven experience in live-cell fluorescence microscopy is a prerequisite. Some knowledge in the DNA repair field will also be appreciated.

Contact Applications should include a CV with a publication list, a motivation letter and contact details for two professional referees. They should be sent to Dr. Sébastien Huet (email: sebastien.huet@univ-rennes1.fr).

Recent publications Zentout et al., PNAS, 2024, doi: 10.1073/pnas.2322689121. Cabriel et al., Nature Phot., 2023, doi: 10.1038/s41566-023-01308-8. D’Augustin et al., Nucleic Acids Res., 2023, doi: 10.1093/nar/gkad243.

Empire Innovations Program/Cluster Hire with the focus on Biological Imaging, Biosensors, Cell Dynamics Analysis, and Optogenetics Department of Cell & Developmental Biology and Department of Biochemistry & Molecular Biology, SUNY Upstate Medical University, Syracuse, New York.    The Departments of Cell & Developmental Biology and Biochemistry & Molecular Biology at SUNY Upstate Medical University in Syracuse, New York, are seeking cluster hires for two tenure-track faculty positions. The cluster hire program is aimed at attracting faculty who are developing new technologies in the areas of imaging, image analysis, cell dynamics analysis, biosensors for detecting disease biomarkers and point-of-care diagnostics, and photomanipulation/optogenetic approaches with potential applications to human health and disease. These Empire Innovation Scholars will complement additional junior faculty hires in the two departments as part of a coordinated expansion effort.

Candidates must have a PhD or equivalent degree in cell or molecular biology, biomedical engineering, biochemistry, physics, or a related field, and currently hold the rank of an assistant or associate professor or a comparable leadership position in private industry. Applicants should have established track records of funding and research productivity. Successful candidates are expected to develop and maintain a vigorous extramurally funded research program and participate in the education of medical and graduate students.   The successful candidates will join a thriving community of over 20 investigators with strengths in using intravital imaging and live-cell imaging to study cardiovascular development, pathogenesis of cancer and neurodegenerative diseases, development and regeneration of vision photoreceptors and immune disorders and development of biosensors and diagnostic assays. Academic appointment will be commensurate with experience and will carry the title of an Associate Professor of Empire Innovation or Professor of Empire Innovation. Preference will be given to candidates currently at the Assistant or Associate Professor level, or comparable rank in industry. 

This position is fully state-supported with a 12-month base salary, excellent health and retirement benefits, and competitive start-up funds. Our faculty are well supported by state-of-the-art imaging resources and outstanding institutional core facilities.      Located in central NY, Syracuse provides a diverse, dynamic, and affordable metropolitan environment with easy access to outstanding recreational opportunities of the Adirondack Mountains and the Finger Lakes. Proximity of SUNY Upstate to Syracuse University and SUNY ESF campuses fosters productive scientific interactions and unique collaborative funding opportunities.    Please apply online to job #82494 at https://bit.ly/UpstateEIP and upload a cover letter, a curriculum vitae, and a research statement (up to three pages) consisting of a summary of accomplishments and description of future plans. Letters of recommendation will be requested separately. 

Review of applications will start November 15, 2024 and continue until the positions are filled.

Further information about the Cell & Developmental Biology and Biochemistry & Molecular biology departments, including additional open positions, can be found at https://www.upstate.edu/cdb/ and https://www.upstate.edu/biochem/. Applicants will be considered for primary appointment in either department depending on fit, but applicants are encouraged to indicate their preference in the cover letter.

At SUNY Upstate Medical University we strive to promote a professional environment that encourages varied perspectives from faculty members with diverse life experiences. A respect for diversity is one of our core values. We are committed to recruiting and supporting a rich community of outstanding faculty, staff and students. We actively seek applications from women and members of underrepresented groups to contribute to the diversity of our university community in support of our teaching, research and clinical missions.

Territory Manager Remote – West Coast Preferred   89 North®, a wholly owned subsidiary of Chroma Technology Corp, develops innovative products for the biomedical imaging market. We focus on development of high-performance light sources for fluorescence-based applications including fluorescence microscopy, automated DNA sequencing, HTS/HCS, real time PCR and microarray analysis   We have an exciting opportunity for a Territory Manager!   JOIN OUR AWARD-WINNING TEAM! Recognized as a Best Places to Work in Vermont and awarded the DCD Outstanding Vermont Business of the Year, Chroma Technology Corp. is a 100% employee-owned company and certified B corporation. We are able to offer an extremely generous package of benefits, rewards, and a value-driven work environment. Join our team of collaborative employee-owners who are self-motivated, independent workers willing to strategize and together work towards the long-term prosperity of the company.   Your Role: The territory manager is responsible for sales activities within a defined geographic region. Exact territorial boundaries will be determined by the successful candidate’s location. These activities include developing and maintaining relationships with end-users (customers) and distributors and resellers, as well as providing feedback from the field on observed trends in the markets served by 89 North. Primary Responsibilities and Essential Functions: ·       Establishes, develops, and maintains distribution networks within territory ·       Provides training and support to distributers within territory ·       Monitors competitor products, sales and marketing activities within territory ·       Manages direct sales of product within territory, including developing a market presence in areas within territory without existing resellers or distributors ·       Establishes and maintains relationships with industry influencers and key strategic partners within their territory ·       Represents company at trade association meetings, as needed ·       Builds on current relationships to gain access to new partners and customers within territory ·       Assists other departments within organization to prepare manuals and technical publications ·       Prepares periodic sales report covering sales, orders and pipeline for territory ·       Prepares periodic sales strategy reports covering areas targeted for expansion and reasoning behind choices and strategy Required Education, Experience, and Eligibility Qualifications: ·       Degree (advanced degree preferred) in life sciences or technical discipline related to imaging ·       3+ years of experience in the field of life science imaging sales, preferably including both distribution and direct customer sales ·       Experience setting up and working with advanced imaging systems ·       Excellent communication and presentation skills ·       Ability to organize and manage multiple priorities ·       Ability to analyze and resolve problems ·       Ability to work effectively with all individuals/groups within the organization ·       Ability to lift up to 30 pounds ·       Ability to travel up to 50% Please visit our career page at www.89north.com to review the full job description, summary of benefits, and to apply online.

89 North is an employee-owned company and equal opportunity employer.  

Sales Account Manager Remote – United States: Southwest, Southeast or Midwest Preferred   Chroma Technology Corp., a world leader in the advanced manufacturing of thin-film optical coatings, has an exciting opening for a Sales Account Manager!   JOIN OUR AWARD-WINNING TEAM! Recognized as a Best Places to Work in Vermont and awarded the DCD Outstanding Vermont Business of the Year, Chroma Technology Corp. is a 100% employee-owned company and certified B corporation. We are able to offer an extremely generous package of benefits, rewards, and a value-driven work environment. Join our team of collaborative employee-owners who are self-motivated, independent workers willing to strategize and together work towards the long-term prosperity of the company.   Job Summary/Objective:   The Sales Account Manager (3) is responsible for developing new, profitable accounts and ensuring that customer needs and expectations are met. This role works to create, retain and mature long term relationships with new and existing OEM, Contract Manufacturer, and Reseller customers and takes an active part in contributing to and formulating sales strategy. This position is tasked with increasing the number and value of accounts, as well as driving expansion into other markets to support Chroma’s continued profitable growth.   Primary Responsibilities and Essential Functions: ·       Account satisfaction; o  Provide quotes for customers to meet their specifications/needs; ·       Works closely with applications, design and methods to ensure the filter design and specification are optimal for the application, and cost effective, while providing a barrier to entry against competition. o  Maintain relationships with clients; ·       Providing support, information, and guidance to customers; ·       Keeping customers apprised of new products and capabilities. o  Act as liaison between the customer and other key departments at Chroma; ·       Assisting in resolving product and service problems by acting as liaison between QA/QC and customer as needed; ·       Providing complete product requirements to Chroma Engineering and facilitating communication between the customer and Chroma during the development process; ·       Participating in trouble shooting. ·       Increase profitable revenue from accounts; o  Increase sales to existing accounts through cross selling and proactively pursuing additional bid opportunities.  o  Participate in market research and assist in developing marketing, advertising and promotional plans, including literature and web-site development. o  Assist in developing product lines for particular applications.  o  Actively seek out new leads, open new markets. o  Use reporting and analytical tools for monitoring key accounts.  o  Maintain detailed customer information in CRM software. o  Use tradeshows to:  ·       Educate customers on offerings (products, capabilities, service); ·       Engage new customers; ·       Strengthen relationships with current customers; ·       Remain current in market innovations and trends; ·       Help map the interplay of companies within the markets of interest. ·       Develop additional accounts by identifying new potential customers through market research, trade show participation, and following up on other leads.  ·       Participate in sales strategy development, competitive benchmarking, and goal setting with Sales Manager and Sales teams.  ·       Maintain technical knowledge by reading publications and attending lectures and workshops that are relevant to the product and markets of interest.  ·       Travel for tradeshows and/or customer visits at least ten (10) times per year; minimum of 20% travel expected. ·       If working remotely full-time, make effort to maintain integrated relationships with pertinent team and department members, including at least semi-annual trips to Bellows Falls, encompassing at least 10 working days per year.   Required Education, Experience, and Eligibility Qualifications:

• Bachelor’s degree in a related field (biology, chemistry, physics or engineering) or equivalent in experience 
• A minimum of 8 years of technical sales and/or support experience and experience in the optics or technically similar industry 
• Strong sales track record and demonstrated ability to grow business 
• Undeniable ability to self-direct and produce while working unsupervised 
• Average to advanced computer skills (user level), including Microsoft Office and Google Suite applications
• Ability to travel as required for the position   Preferred Education, Experience, and Eligibility Qualifications:
• Knowledge of filter manufacturing, design, underlying science and technologies, and applications (including fluorescent imaging)
• Bilingual fluency helpful: German, Japanese, and/or Mandarin   Please visit our career page at www.chroma.com to review the full job description, summary of benefits, and to apply online.

Chroma Technology Corp is an employee-owned company and equal opportunity employer.

Job Description Summary Supports microscopy related research and teaching in the Microscopic Imaging Core of Wake Forest University Biology by assisting the Director of Microscopy.

Job Description Essential Functions:

• Trains new users and assists in utilization of microscopes and related equipment.
• Maintains microscopes and related equipment in a clean and highly operational state.
• Communicates an excitement about imaging-related science to new students and visitors.
• Facilitates scheduling of equipment use and related record keeping/reporting.
• Reports to and coordinates overall activities with the microscopy director.
• Assists the director in other microscopy facility related directives as assigned.
• Assists undergraduates, graduate students, and faculty with design and implementation of experimental protocols related to microscopy by understanding research goals and needs of individual facility users.

Additional Job Description Accountabilities:

• Responsible for own work.
• Provides training and assists in the supervision of graduate and undergraduate student researchers.
• Reports activities and problems to the facility director. Physical Requirements:
• Sedentary work primarily involving sitting/standing; communicating with others to exchange information; repeating motions that may include the wrists, hands, and/or fingers; and assessing the accuracy, neatness, and thoroughness of the work assigned. 
• Ability to travel 7 miles between Innovation Quarter and main Reynolda campus (university shuttle or personal car) Disclaimer: This position profile identifies the key responsibilities and expectations for performance. It cannot encompass all specific job tasks that an employee may be required to perform. Employees are required to follow any other job-related instructions and perform job-related duties as may be reasonably assigned by the employee’s supervisor.

We have funded postdoc positions available in the Carpenter-Singh lab in Cambridge MA USA (Broad Institute of Harvard and MIT), paying $70,000 (or more with years of experience post-PhD) with a flexible start date.

There are two projects: - Rapidly identifying disease phenotypes from rare disease variants, and drugs to reverse their impact (as part of the NIH IGVF Consortium https://www.youtube.com/watch?v=8RcsC4a2Ews&list=PLJG0u60zazOtRAwamVGhaJ6eGqh-HASvw&index=6) - Using Cell Painting, transcriptomics, and proteomics data to predict toxicity of drugs and agrochemicals (as part of the OASIS Consortium https://oasisconsortium.org)

Both projects will have copious data produced by this time next year!

Summary Elephas, a Madison, WI-based biotechnology start-up company, seeks a talented individual to join our team as a Software Engineer specializing in fluorescence microscopy, multi-photon or Optical Coherence Microscopy (OCM) microscopes for biological applications. Applicants should be comfortable in a fast-paced and collaborative environment. The successful candidate will be a skilled and experienced software engineer who will contribute to developing, optimizing, and validating Elephas’ cancer diagnostics platform.

Essential Duties and Responsibilities

• Develop and optimize image analysis, signal processing and visualization solutions for combining multi-photon, OCT/OCM, slide scanning, and widefield microscopes used in biological imaging.
• Collaborate with interdisciplinary teams to understand and translate system requirements into efficient and reliable software solutions.
• Analyze and troubleshoot system issues, provide technical support, and propose innovative solutions.
• May assist with control system development (novel development).
• Stay up-to-date with the latest advancements in imaging technologies, identifying opportunities for improvement and innovation.
• Follow a regulated software development methodology in an agile environment.
• Align with the Elephas values: Deliver patient-centric solutions, Deliver quality, Be science-driven, Be curious and innovative, Be generous and honest, and Be a good partner and teammate.

Education/Experience/Skills

• Master’s or PhD in Computer Science, Computer Engineering, Applied Mathematics or a similar field, or applicable industry experience.
• Strong experience with C++ and C, with a minimum of 5 years of experience.
• Proficiency in troubleshooting compile-time errors.
• Expertise in multiprocess communications.
• Experience in combining languages, such as using a C++ library in Python or Matlab.
• Proficiency in C# preferred.
• Strong graphics programming skills in DirectX, Vulcan, OpenGL, Metal, or similar.
• Experience with time-lapse animation or gaming interface and design is preferred.
• Proficiency in image analysis.
• Experience in high-performance computing.
• Experience coding in a team environment, including version control and code reviews.
• Proficiency with Linux, Windows, and Mac operating systems.
• Experience with Matlab, Octave, and R is preferred.
• Strong mathematical skills
• Strong problem-solving and analytical skills, with the ability to work independently and collaboratively in a dynamic team environment.
• Excellent communication skills and the ability to effectively present technical concepts to technical and non-technical stakeholders.   We offer our employees competitive compensation and benefits, including paid time off, health insurance, life insurance, flexible spending accounts, a 401(k) plan, and stock options. Relocation assistance is available. Qualified candidates should forward their resumes to mcostin@elephas.com or apply through the careers section on our website, https://elephas.com/join-elephas.

DISCLAIMER The preceding job description has been designed to indicate the general nature and level of work performed by employees within this classification. It is not designed to contain or be interpreted as a comprehensive inventory of all duties, responsibilities and qualifications required of employees assigned to the job.   We are an Equal Opportunity Employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity, status as a veteran, and basis of disability or any other federal, state or local protected class.

ARISE2 targets technology and method development experts with STEM backgrounds who are interested in using their expertise to advance research in the life sciences. To address urgent challenges to human and planetary health new technologies and services are needed in the Life Sciences. ARISE2 is designed to meet this need by training fellows in the development of technologies and methods for improvement of scientific services, while also preparing them for careers in research infrastructures (RI) to make these advances available to the scientific community accelerating progress.   ARISE2 is an MSCA-funded postdoctoral fellowship programme offering talented STEM fellows from around the world the unique opportunity to work on the development and/or improvement of technologies for Life Science Research while developing the expertise needed for a career in research infrastructures making them sought after experts both in academia and industry.

The Meyer lab (meyerlab.yale.edu) is part of the Department of Molecular, Cellular and Developmental Biology, and the Systems Biology Institute at Yale University. We seek to understand the molecular logic of cellular decision making in the context of embryonic development. We study mechanisms of gene regulation with a particular focus on the role of chromatin mechanics/biophysics in sensing, processing, and memorizing information. To this end, we synthetically control signaling nodes (optogenetics, synthetic biology tools) and combine this approach with imaging-based readouts to record information flow at molecular resolution (single molecule imaging). We are seeking a passionate, motivated, and open-minded postdoctoral researcher to join our team and help build a single-objective oblique plane light sheet microscope for single-molecule imaging. This project, supervised in collaboration with experts in the light sheet community, offers a unique opportunity to contribute to cutting-edge imaging technology and explore its applications to understand principles of gene regulation. Applicants must have a PhD and prior experience in microscopy/optics, physics, or related fields. To apply, please submit a cover letter outlining your motivation and include contact information for three references to kirstin.meyer@yale.edu. For more information, please see meyerlab.yale.edu.

The role will focus significantly on mesoSPIM microscope support, advanced image analysis, and data management. This position will work with the Director of the MDIBL Light Microscopy CORE Facility and interface significantly with Director of the MDIBL Comparative Genomics and Data Science (CGDS) Core.

Sous l’autorité hiérarchique de la cheffe des plateformes scientifiques, mais en supervision immédiate avec la responsable de la plateforme, en étroite collaboration avec les directeurs scientifiques, les tâches et responsabilités principales du spécialiste technique en microscopie seront :

• Agir à titre de personne-ressource auprès des chercheurs, du personnel de recherche et des étudiants pour les besoins en microscopie optique;
• Participer aux rencontres statutaires des opérations avec la responsable de la plateforme et la Cheffe des plateformes scientifiques ;
• Travailler en équipe avec le personnel de la plateforme;
• Participer à la formation des étudiants et personnel de recherche aux principes de la microscopie optique et à l'utilisation des différents appareils et logiciels d'analyses ;
• Collaborer avec la responsable de la plateforme à l’offre de service d’assistance et conseils aux étudiants, personnel de recherche et chercheurs pour les aspects scientifiques et techniques de leurs projets de recherche;
• Assurer l’inspection, la mise en marche des microscopes, la maintenance de routine et résoudre les problèmes techniques ;
• Accompagner les utilisateurs dans les tâches d'analyse d'images;
• Vérification et remplissage des fournitures de microscopie;
• Participer aux tâches administratives telles que la surveillance des journaux d'utilisation (logs), l'impression du matériel de formation, l'édition des rapports;
• Aide au développement continu du portail de réservation et de facturation en ligne.

Aptitudes et qualités requises

• Faire preuve d'autonomie et d'initiative;
• Débrouillardise et excellentes compétences dans la résolution de problème;
• Bonnes habilités interpersonnelles et excellent service à la clientèle;
• Capacité à gérer efficacement les priorités;
• Sens de l'organisation et gestion du temps;
• Maitrise du français écrit et parlé (anglais un atout) ;
• Attention au détail.  

JOB DESCRIPTION AND POSITION REQUIREMENTS:

A full-time Microscopy Imaging Scientist / Research Technologist position is available in the Advanced Light Microscopy Core (ALM) at Penn State College of Medicine in Hershey, PA. ALM supports researchers by providing consultations, trainings, and assisted sessions on advanced microscopes and image processing/analysis. Current microscopes include a DeltaVision Elite (widefield), a Leica SP8 STED 3X (confocal/STED), a Leica SP8 FALCON (confocal with FLIM/FCS), and a Miltenyi Biotec UltraMicroscope II (light-sheet for cleared samples). A Nikon CSU-W1 SoRa super-res spinning disk confocal microscope will be purchased soon. Commercial image visualization/analysis/processing software--Imaris and SVI Huygens--are located on ALM workstations. Responsibilities:

• Manages ALM and leads other ALM staff to support and advance research
• Trains and assists researchers with the execution of advanced imaging experiments (experimental design, how to acquire quantifiable data, image analysis)
• Ensures microscopes/workstations are in excellent working order
• Supports users with troubleshooting
• Interacts with vendors for troubleshooting, service contracts, scheduling visits, etc.
• Responds to researcher inquiries in a timely fashion during working hours
• Organizes teaching and educational events
• Uses iLab for administrative tasks such as scheduling and billing
• Works with faculty members to secure funding for additional instrumentation
• Other related functions as assigned

Minimum Education & Experience:

Bachelor's Degree 6+ years of relevant experience Or an equivalent combination of education and experience

Preferred qualifications:

• PhD in a related field
• Experience with other microscopy modalities (spinning disk, STED, light-sheet)
• Experience with fluorescence lifetime imaging or fluorescence correlation spectroscopy
• Experience with bioimage analysis/processing using ImageJ/Fiji and Python
• Experience in developing and/or implementing research methods
• 2+ years of experience working in a core facility / shared resource environment
• Understanding of optics, light microscopy, and digital images
• Extensive hands-on experience with laser scanning confocal microscopy
• Knowledge of fluorescence microscopy sample preparation methods
• Experience with training others on microscopes and/or bioimage analysis
• Knowledge of best practices for digital image processing
• Proactive, well-organized, and able to work independently and in a team
• Strong oral and written communication skills in English
• Soft skills to work in a customer-facing role

This is a limited-term position funded for one year from date of hire, with possibility of refunding.  The following clearances must be successfully completed for this position:  

• Pennsylvania State Police Criminal Background Check  
• Pennsylvania Child Abuse History
• Federal Bureau of Investigation (FBI) Criminal Background Check      The Pennsylvania State University is committed to and accountable for advancing diversity, equity, and inclusion in all of its forms. We embrace individual uniqueness, foster a culture of inclusive excellence that supports both broad and specific diversity initiatives, leverage the educational and institutional benefits of diversity, and engage all individuals to help them thrive. We value inclusive excellence as a core strength and an essential element of our public service mission.   The salary range for this position, including all possible grades is: $51,000.00 - $74,000.00

The Fritz-Laylin Laboratory is looking for a Research Specialist to join their lab at the University of Massachusetts Amherst. Organismal diversity, essential to life as we know it, relies on variability in cell form and function. The Fritz-Laylin laboratory studies the evolution and diversification of the cytoskeleton, an internal scaffolding system that varies wildly among cell types and species, leading to diversity at the organismal level. This work requires understanding the cytoskeletal biology of diverse species, including those from unexplored parts of the tree of life. The Fritz-Laylin lab develops genetic tools to study the cytoskeletal biology of historically neglected lineages, focusing on organisms that occupy pivotal evolutionary positions, exhibit remarkable cytoskeletal biology, and are important for human health and global ecology. To support this work, the lab is seeking a microscopist fluent in transmitted and fluorescence light microscopy and data analysis. More information about the lab and their work can be found by visiting https://www.fritzlaylinlab.org/ A major aspect of the position will be to meet regularly with lab members and help them design microscopy experiments and implement image analysis protocols and pipelines, including strong proficiency in image analysis using at least one of the following: ImageJ/FIJI Cell Profiler Python MatLab What we provide:

• A competitive compensation package with comprehensive health and welfare benefits.
• A research environment focused on skill development for all lab members. Dr. Fritz-Laylin is committed to helping all lab members build the skills needed to achieve their long-term career goals. Such skills include biological knowledge, technical and analytical methods, project management, as well as science communication in the form of oral presentations, scientific publication, and grant writing. Dr. Fritz-Laylin meets with lab members weekly to discuss research progress and training needs.
• The opportunity to join the University of Massachusetts Amherst Community. The University sits on nearly 1,450-acres in the scenic Pioneer Valley of Western Massachusetts and offers a rich cultural environment in a bucolic setting close to major urban centers. In addition to being the Commonwealth's flagship campus and a nationally ranked public research university, the University is part of the Five Colleges (including Amherst College, Hampshire College, Mount Holyoke College, and Smith College), which adds to the intellectual energy of the region. What you’ll do:
• Maintain all microscope equipment including day-to-day maintenance, as well as interfacing with company reps for larger repairs as needed.
• Maintain computers associated with microscopes as well as image-processing computers.
• Maintain image acquisition and analysis software.
• Demo new microscope equipment and help the lab decide which new equipment to purchase to extend our capabilities to possibly include: TIRF microscopy, Upgraded spinning disc confocal microscopy, Light sheet and/or scanning confocal microscope, FRAP/Photoactivation capabilities.
• Draft and edit methods and results sections of papers.
• Train lab members on the use of microscopes and help them to troubleshoot imaging experiments. To this end, the candidate should be proficient in the following imaging modalities: Confocal microscopy, Widefield epifluorescence, DIC, Phase, Darkfield, TIRF, IRM/RICM. What you bring:
• Master of Science degree in an appropriate field of science or technology, PhD preferred.
• One year of experience as a Research Specialist I or equivalent (Five years of related work experience).
• Technical proficiency, scientific creativity, collaborative ability as well as independent thought.
• Ability to work inclusively and collaboratively with diverse population.
• Ability to monitor the performance of others and identify areas where additional training can further research goals.
• Ability to develop innovative processes to achieve goals. Directs others to develop essential tasks. Reviews work activities to determine where new information could improve processes or move projects forward.
• Ability to write and prepare reports or manuscripts for presentation to large audiences. Physical Requirements Remaining in a normal seated or standing position for extended periods of time; reaching and grasping by extending hand(s) or arm(s); dexterity to manipulate objects with fingers, for example using a keyboard; communication skills using the spoken word; ability to see and hear within normal parameters; ability to move about workspace. The position requires mobility, including the ability to move materials weighing up to several pounds (such as a laptop computer or tablet). Work may involve possible exposure to malodorous vapors, low dose radiation, contamination by toxic chemicals and acids and presence of carcinogenic substances or other hazardous materials. Persons with disabilities may be able to perform the essential duties of this position with reasonable accommodation. Requests for reasonable accommodation will be evaluated on an individual basis. Please Note: This job description sets forth the job’s principal duties, responsibilities, and requirements; it should not be construed as an exhaustive statement, however.  Unless they begin with the word “may,” the Essential Duties and Responsibilities described above are “essential functions” of the job, as defined by the Americans with Disabilities Act.

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  Compensation and Benefits Our employees are compensated from a total rewards perspective in many ways for their contributions to our mission, including competitive pay, exceptional health benefits, retirement plans, time off, and a range of recognition and wellness programs. Visit our Benefits at HHMI site to learn more.  Compensation Range $63,900.00 (minimum) - $79,832.48 (midpoint) - $103,800.00 (maximum)Pay Type: AnnualHHMI’s salary structure is developed based on relevant job market data. HHMI considers a candidate's education, previous experiences, knowledge, skills and abilities, as well as internal equity when making job offers. Typically, a new hire for this position in this location is compensated between the minimum and the midpoint of the salary range. HHMI is an Equal Opportunity Employer

The FIB-SEM Collaboration Core (F-SCC) at Yale School of Medicine is seeking a talented, skilled, and highly motivated researcher to assume the role of Senior Staff Scientist (90282BR). The candidate will play a leadership role in managing and performing electron microscopy (EM) sample preparation and FIB-SEM sample preparation operations. At the forefront of volume Electron Microscopy, the F-SCC utilizes the state of the art enhanced Focused Ion Beam Scanning Electron Microscopy (FIB-SEM) technology for large volume imaging with nanometer isotropic resolution. Under supervision of the Director, the candidate will be responsible for optimizing the existing electron microscopy (EM) sample preparation protocols of biological specimens, developing new methods for clinical specimens, and establishing an automated EM sample preparation pipeline. The candidate is expected to perform independent research, experiments, and laboratory techniques, and work closely with supervisor, group members, and collaborators.