Job Openings

Advanced Light Microscopy & Image Analysis (ALM) Technology Platform is looking for a curious, creative, and motivated Imaging Scientist/Postdoc with a background in fluorescence microscopy and/or light-sheet imaging and molecular/cellular biology (part-time, 30 hrs/week) to implement correlative light-sheet and MR imaging of cardiovascular structures in the frame of a VASBIO grant funded project and to support the ALM team in everyday user support. ALM as part of the MDC scientific infrastructures supports 17 imaging setups and enables a wide portfolio of imaging technologies, ranging from super-resolution, TIRF and confocal microscopy to light-sheet imaging (Blaze UM, Zeiss Z7) and 2-Photon/intravital microscopy as well as high-multiplex spatial phenotyping. In addition, ALM supports researchers with sample clearing & labelling and image data analysis. In collaboration with MDC researchers, ALM works to advance imaging methodologies and deepen insights into disease mechanisms. https://www.mdc-berlin.de/advanced-light-microscopy Job Description The tasks of the imaging specialist include (but are not limited) to two main duties: In the frame of a VASBIO grant-funded project in collaboration between ALM and the Berlin Ultrahigh Field MRI facility at MDC: ·       Establishment and optimization of sample clearing and labeling as well as light-sheet imaging of cardiovascular tissue structures. ·       Optimization of data processing and analysis of light-sheet images and correlation with MRI images. As part of the general ALM user and project support: ·       Support researchers by training, assistance and troubleshooting in executing advanced imaging experiments, with a focus on confocal microscopy. ·       Maintain microscopes in optimal working condition. This position is limited to 1 year. For inquiries, please contact: Dr. Anje Sporbert (ALM TP leader): asporb@mdc-berlin.de and Dr. Min-Chi Ku (Berlin Ultrahigh Field MRI facility): min-chi.ku@mdc-berlin.de

Requirements Applicants should have a degree (MSc required, PhD preferred) in life sciences, physics or similar. Profound experience in the area of light microcopy (fluorescence microscopy and additional advanced microscopy methods) is preferred for this position. Expertise in light-sheet imaging, sample clearing or data processing would be a strong plus.   Further requirements are:

• passion scientific technology support and service attitude, self-motivation, pro-active attitude, responsible and independent project handling
• motivation and interpersonal skills to interact with researchers
• excellent organizational and communication skills
• professional command of both spoken and written German or English

This project will investigate disease causing genetic variants in lipodystrophies and cardiovascular disease, using zebrafish and in vitro models.

Applications are invited for a postdoctoral research position to develop methods for processing, analysing and visualising multimodal advanced microscopy data.

This project focuses on how metabolism can be investigated using a range of microscopy methods, including fluorescence lifetime imaging (FLIM) and optical coherence techniques, for a variety of biological systems. You will work collaboratively as one of five multidisciplinary postdoctoral researchers to develop microscope technology across length-scales from the molecular to whole organ. A critical component of this work will be a software platform which will allow integration of information from different imaging modalities and methods for exploring and visualising this data. The candidate will develop this software as plugins for the python-based multi-dimensional data viewer napari. The analytical methods development will involve aggregating existing techniques for FLIM analysis into one package, registration of large multi-dimensional datasets, and machine learning/AI to explore how information is shared between different imaging modalities.

Candidates are welcomed from a range of backgrounds across biology, physics and computer science. As the role will heavily involve software development, experience of programming is essential.

Access to excellent training and world class facilities will be provided, with opportunities to attend international conferences within the field.

This is a full time post funded by the Wellcome Trust and you will be offered an 11-month fixed term contract with a start date no sooner than 1st March 2025.

The role is suitable for a flexible working pattern with an expected minimum of two days per week on site.

Liverpool John Moores University (LJMU) is a distinctive, unique institution, rooted in the Liverpool City Region and with a global presence. Our students and staff, past, present, and future, are the beating heart of our city and can be found in every corner of every industry and community. We couldn’t exist anywhere else and have shaped the city in which we belong. Working with the people of Liverpool to improve lives and support communities is at the heart of why we were founded and why we exist today. We are seeking a proactive and highly skilled senior specialist technician to oversee the day-to-day operations of our state-of-the-art imaging and microscopy facilities at LJMU. This critical role involves managing advanced imaging technologies, including Electron Microscopes (TEM, SEM), confocal microscopy, and other fluorescence microscopy equipment.  You will be pivotal in ensuring high-quality service delivery for teaching, research, and consultancy, while maintaining health and safety compliance, supporting academic and research activities, and driving innovation within the suite. We encourage applications from experienced technical specialists with expertise in microscopy and imaging technologies, with strong organisational skills and the ability to provide training and support to a diverse group of users.  In return, we offer an excellent benefits package including generous annual leave entitlement, pension scheme, induction and development support as well as family-friendly policies. This is an exciting time to join the university as we deliver the LJMU Strategy 2030 and its vision of LJMU as an inclusive civic university transforming lives and futures, by placing students at the heart of everything we do. If you feel that this is the role you have been looking for and your skills and experience can make a real difference at LJMU, we look forward to hearing from you. LJMU is an equal opportunities employer and welcomes applicants from all backgrounds and communities irrespective of age, transgender status, disability, gender, sexual orientation, ethnicity and religion or belief. All our appointments are made on merit. Please note all of our vacancies will be closed to applications at midnight on the advertised closing date, unless otherwise stated.

LJMU Vacancies: https://jobs.ljmu.ac.uk/home.html

We invite you to join our interdisciplinary international team and develop breakthrough approaches to predict long-term health hazards of materials. You will contribute to the discovery and understanding of the early mechanisms through which nanomaterials trigger long-lasting health effects by combining cutting-edge live-cell microscopy, biophysics, biology and computer modelling. We will support you in applying your basic scientific research to develop new tools for fast and cost-efficient safety assessment, which will be efficiently passed into real-life settings through our ties to regulators and industrial partners to protect workers and consumers.

If you have a strong research interest in the bio-fields, an open mind to challenge the dogmas, and if you enjoy teamwork and working on projects of varying sizes, we encourage you to apply. Experience in bio-imaging, optics, image analysis, wet lab work and programming is highly welcome.

Candidates should submit a personally written motivation letter (max 1 page), a structured CV, a comprehensive list of publications, and at least two references. Applications should be sent to Janez Štrancar (janez.strancar@ijs.si) and Iztok Urbančič (iztok.urbancic@ijs.si) with the subject line “Postdoc position” or directly via the apply button.

The call is open for applications until 15th December 2024, early submissions may accelerate the interview process.

We have a funded 4-year PhD studentship starting in Sept 2025. This will use the new "Multiscope" parallelised microscope to study the effect of neuroendocrine signalling on feeding behaviour. Answer fundamental bioscience questions using high throughput imaging. Please get in touch!

The Vienna BioCenter Core Facilities (VBCF) provide cutting-edge research infrastructure and expertise that form the foundation of groundbreaking discoveries at the Vienna BioCenter (VBC), home to multiple research institutes (including IMP, IMBA, GMI, Max Perutz Labs, University of Vienna Biology Building), companies, and around 2,000 scientists. Situated at the VBC campus, the VBCF GmbH provides scientific services to research on campus and beyond, supported by the extensive expertise of over 80 trained scientists and technicians. The VBCF is currently seeking a:

Head of Plant Sciences Core Facility (f/m/d, full-time) for our Plant Sciences team. This role involves advancing our cutting-edge research in high-throughput plant phenotyping, while also overseeing the maintenance and optimization of phytotrons to support essential plant growth and experimental services. A detailed overview of our offered services can be found on our website.

• Key responsibilitiesLead and manage a state-of-the-art, multi-sensor, high-throughput plant phenotyping research infrastructure - #PHENOPlant.
• Lead and further develop a diverse service portfolio: high-throughput plant phenotyping - technology development (prototyping) - software development - data analysis.
• Lead and evaluate scientific projects to drive innovations in plant phenotyping, focusing on high-throughput data acquisition and image processing.
• Coordinate and further develop the Austrian Plant Phenoytping Network (APPN) supporting the EU ESFRI EMPHASIS project.
• Oversee the routine operation and maintenance of phytotrons and glasshouses, ensuring optimal plant growth conditions for research.
• Manage lab organization and instrument maintenance to ensure efficient workflows and consistent service quality.
• Develop and implement new protocols to enhance the facility’s service offerings in plant sciences.
• Train and guide an interdisciplinary team, fostering a collaborative and customer-oriented environment.
• Engage with national and international customers to understand their scientific needs and provide impactful research support. Carry out business development and new customer acquisition.

Pictura Bio is seeking a skilled Prototype Engineer for a short-term project focused on developing a smartphone-enabled fluorescence microscopy system for imaging pathogens. The project entails building and refining a compact, smartphone-compatible imaging setup. The ideal candidate will have a strong background in optics and fluorescence microscopy, with hands-on experience adapting optical systems for smartphone integration. Requirements:

1. Deep expertise in optics and fluorescence microscopy.
2. Proven experience in designing and prototyping smartphone-compatible imaging systems.
3. Strong ability to work independently and troubleshoot technical challenges.
4. Availability for a short-term, hands-on project. How to Apply: Please contact nicolas.shiaelis@pictura.bio.

As Senior Data Scientist, you will be responsible for:

• Designing and developing image analysis pipelines for spatial genomics and high-content screening data
• Collaborating with our team of scientists and engineers to understand imaging data and develop efficient solutions
• Troubleshooting problems on a day-to-day basis and escalating issues outside of your expertise
• Communicating results through presentations, posters, and meetings with collaborators
• Executing and maintaining existing imaging-based analysis pipeline services

About You To excel in this role you will need the following:

• MSc or Ph.D. in a relevant quantitative discipline (e.g., Computer Science, Computational Biology, Genetics, Bioinformatics)
• Experience working with image analysis tools such as QuPath, OMERO, Napari, and Fiji
• Knowledge of software development good practices and collaboration tools (git-based version control, Python package management, Docker/Singularity)
• Excellent communication skills to explain complex image analysis algorithms to non-technical stakeholders
• Ability to organize, plan, and prioritize tasks or projects

Do you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity’s greatest challenges. Are you passionate about image analysis, software development, and collaboration with scientists? Do you have a knack for designing and developing efficient image analysis pipelines? We are looking for an experienced Data Scientist / Image Analysis Developer to join our team and contribute to cutting-edge research in the field of genomics. As a key member of our imaging team, you will work closely with scientists and engineers to develop innovative solutions for interdisciplinary scientific problems.

About the Role As Senior Data Scientist, you will be responsible for:

• Designing and developing image analysis pipelines for spatial genomics and high-content screening data
• Collaborating with our team of scientists and engineers to understand imaging data and develop efficient solutions
• Troubleshooting problems on a day-to-day basis and escalating issues outside of your expertise
• Communicating results through presentations, posters, and meetings with collaborators
• Executing and maintaining existing imaging-based analysis pipeline services

About You To excel in this role you will need the following:

• MSc or Ph.D. in a relevant quantitative discipline (e.g., Computer Science, Computational Biology, Genetics, Bioinformatics)
• Experience working with image analysis tools such as QuPath, OMERO, Napari, and Fiji
• Knowledge of software development good practices and collaboration tools (git-based version control, Python package management, Docker/Singularity)
• Excellent communication skills to explain complex image analysis algorithms to non-technical stakeholders
• Ability to organize, plan, and prioritize tasks or projects

The Bio-Imaging Resource Center (BIRC) at the Rockefeller University in New York City is seeking a motivated full-time microscopist to advise and train users on our commercial microscopes and to push these systems to new levels! In addition, the applicant will liaise with the image analysts in the BIRC and also with our optical engineer, who is building pre-commercial light sheet systems in our satellite laboratory.

Summary: The Ragon Institute is a highly unique, innovative, and collaborative research center at the forefront of biomedical science. Founded by Massachusetts General Hospital, MIT, and Harvard, the Ragon vision is a bold one: to harness the power of the immune system to prevent and cure human disease on a global scale. This vision is pursued and advanced every day by a group of highly motivated individuals. The Ragon Institute, at every level, depends upon collaboration, compassion, dedication, and innovation.  It is a results-oriented organization that seeks people who not only embrace these values but who thrive in teams and want to work in a dynamic environment.

At the Ragon Institute, people are our greatest asset.  In this role, the Microscopy Director will be an integral part of the evolution of the organization.  They will be responsible for overseeing the daily operations and financial solvency of the Ragon’s current microscopy core, but they will also play a critical role in helping to evolve and grow the facility.  Specifically, the Microscopy Director will manage state-of-the-art fluorescence microscopy equipment s, supporting a wide range of scientific research across multiple disciplines, including immunology, tissue biology, cell biology, and microbiology. The Director will also be responsible for ensuring the microscopy facility operates at the highest standards, providing technical expertise, training, and support to researchers, and driving innovation in imaging techniques and technologies.

The ideal candidate is a highly skilled scientist with deep expertise in advanced microscopy techniques, a proven track record of supporting cutting-edge research, enjoy collaborating with multi-disciplinary teams, thrive on creating new processes, and possess strong leadership and management abilities.  Ultimately, they will be a strategic thought partner and a trusted advisor to the core users and Ragon leadership team. Primary Duties and Responsibilities: Leadership and Oversight:

• In collaboration with end-users, develop and implement a strategic plan for the facility, ensuring that it stays at the forefront of microscopy technology and research capabilities.
• Compare the core to peer institutions’ resources through benchmarking studies.
• Identify appropriate facility operating metrics and regularly analyze data.
• Develop a process to track core utilization and optimization.
• Present programmatic and financial data analysis on core performance to a variety of audiences.
• Advise the Executive Team and Faculty regarding the scientific appropriateness and value of current / new equipment for the core.
• Ensure compliance with MGH, Ragon, and US Federal regulations as they apply to core facilities. Facility Management and Operations:
• Lead and manage all microscopy operations, ensuring the smooth functioning and availability of instruments, technology platforms, and services to researchers.
• Determines and writes user policies for the facility.
• Stay updated on the latest microscopy advancements and disseminate best practices across the research community.
• Develop educational programs, workshops, and seminars to enhance the knowledge and skills of microscopy users within the organization.
• Lead the training and mentorship of scientists, students, and staff in microscopy techniques, image acquisition, and analysis. Research Support and Collaboration:
• Work closely with researchers across various scientific disciplines to design and optimize microscopy experiments, providing guidance on the best imaging techniques, protocols, and analyses for their scientific questions.
• Collaborate with investigators to develop novel imaging approaches and methods, facilitating high-impact publications and discoveries.
• Act as a liaison between the microscopy core and research groups, ensuring that services are aligned with the evolving needs of the scientific community. Financial Oversight
• Collaborate with the Ragon Finance Team and Imaging Committee in creating long and short-term business plans and yearly budgets.
• Monitor budgets to ensure fiscal solvency.
• Report on core performance; investigate and provide resolution options to remedy variances from expected to actual business and performance indicators.
• Maintain accurate records of facility usage for reporting and billing purposes.
• Oversee safety protocols and ensure compliance with all relevant regulations regarding the use of microscopes and related technologies. Equipment Management and Innovation:
• Oversee the maintenance, calibration, and upgrades of all microscopy equipment, ensuring optimal performance and data quality.
• Drive innovation by introducing new microscopy technologies, imaging modalities, and advanced techniques such as high-resolution multiplexed confocal imaging (both in tissues and cells), cleared 3D organ imaging, multiphoton imaging, spatial omics, FLIM, and live-cell imaging.
• Collaborate with vendors and suppliers to evaluate and acquire new instruments that enhance the facility’s capabilities.
• Advise the space committee around the physical space requirements for institutional shared research cores. Data Management and Analysis:
• Oversee data acquisition, processing, and image analysis workflows, ensuring that high-quality imaging data is collected and stored appropriately.
• Implement and provide support for advanced image analysis software and tools (e.g., Imaris, Avia, Arivis, Napari, ImageJ etc.), ensuring that researchers can effectively analyze complex datasets.
• Promote the integration of microscopy data with other scientific datasets to support multi-modal analysis and advanced research. Grant Writing and Funding:
• Support researchers in the preparation of grant applications by providing technical expertise related to microscopy techniques and experimental design.
• Lead and contribute to the development of facility-based grants to enhance the microscopy core’s capabilities and support infrastructure improvements.     Education:
• PhD in biology, biophysics, biomedical engineering, or a related field with significant experience in advanced microscopy techniques.

Experience:

• 7+ years of experience in fluorescence microscopy, including but not limited to confocal, live-cell  light sheet, multiphoton, and super-resolution microscopy, with a strong record of publications or research contributions. Experience with modern multiplexed tissue/organ imaging techniques is highly advantageous.
• Ideally, extensive experience in managing or directing a microscopy core facility or research laboratory.
• Proven ability to collaborate with and support researchers in designing microscopy experiments across diverse scientific disciplines.
• Prior experience in an academic setting highly preferred.

Skills:

• Deep expertise in advanced microscopy techniques and imaging modalities.
• Proficient in microscopy software and image analysis tools (e.g., ImageJ, Imaris, or similar).
• Strong leadership and management skills, with experience in supervising staff and training users.
• Excellent communication and interpersonal skills to interact with a broad range of researchers and stakeholders.
• Ability to troubleshoot complex technical issues and optimize imaging protocols for scientific rigor.

Preferred Qualifications:

• Significant experience with light and fluorescence microscopy, including live-cell confocal, super-resolution, light sheet and other  and specialized imaging techniques.
• Experience in quantitative image analysis. A familiarity with modern machine learning and artificial intelligence applications in image analysis is a benefit.
• Experience with grant writing and securing funding for microscopy-related research or infrastructure.

Work Setting: M-F, 8:30 am – 5 pm, on-site

The above job description details the major duties and qualifications of the listed position. The individual hired to this position confirms that they are able to perform all duties outlined. Although the specific duties and responsibilities of this position may vary slightly, the supervisor of this position will ensure that the individual hired to this position is trained and qualified to complete each task assigned.    EEO Statement   Massachusetts General Hospital is an Affirmative Action Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.    Primary Location MA-Cambridge-MGH Ragon Institute Work Locations MGH Ragon Institute 600 Main St  Cambridge 02139 Job Research - Other Organization Massachusetts General Hospital(MGH) Schedule Full-time Standard Hours 40 Shift Day Job Employee Status Regular Recruiting Department Ragon Institute Job Posting Oct 11, 2024

Project title Analysis of the dynamics of DNA repair proteins using single molecule tracking in living cells.

Job description One research engineer position is available in the group of Sébastien Huet for a period of 2 years starting early 2025. The team belongs to the Institut de Génétique et du Développement de Rennes (http://igdr.univ-rennes1.fr/). It is currently composed of seven people with complementary expertise (molecular and cellular biology, biophysics, fluorescence imaging, mathematical modeling). The team is interested in the analysis of the early steps of the DNA repair mechanisms, focusing on the behavior of the two first responders PARP1 and OGG1 which detect single-strand breaks or 8-oxoguanine, respectively. Using advanced live-cell imaging approaches, the team investigates the target-search mechanisms used by these two factors to efficiently find their cognate lesions along the genome and characterizes their dynamic association with these lesions. The recruited engineer will be involved in the development of single-molecule imaging approaches to track individual fluorescently tagged PARP1 and OGG1 in living cells. These developments will be performed in close collaboration with the lab of Ignacio Izeddin from the Institut Langevin in Paris.

Qualifications The applicant should hold a PhD in biophysics or cell biology. A proven experience in live-cell fluorescence microscopy is a prerequisite. Some knowledge in the DNA repair field will also be appreciated.

Contact Applications should include a CV with a publication list, a motivation letter and contact details for two professional referees. They should be sent to Dr. Sébastien Huet (email: sebastien.huet@univ-rennes1.fr).

Recent publications Zentout et al., PNAS, 2024, doi: 10.1073/pnas.2322689121. Cabriel et al., Nature Phot., 2023, doi: 10.1038/s41566-023-01308-8. D’Augustin et al., Nucleic Acids Res., 2023, doi: 10.1093/nar/gkad243.

Norlin lab is expanding and seeking new team members. We are looking for a postdoctoral fellow in optics engineering and microscopy driving and or supporting projects in light-sheet/oblique plane microscopy, lensless-, smart- and light-field microscopy. In these highly collaborative projects, you will have the chance to develop novel microscopy techniques to cover new grounds in single cell and tissue biology. The lab is located at the department of experimental medical science and has extensive collaborations with researchers at the medical faculty as well as Nanolund and the Lund university bioimaging centre.   We’re seeking candidates with a Ph.D. in optics engineering, light microscopy, or related fields with practical experience in building optical setups. Knowledge of molecular biology / life science is recommended but no requirement. We are looking for an openminded, positive and self-motivated team player with excellent written and verbal communication skills in English. 

Empire Innovations Program/Cluster Hire with the focus on Biological Imaging, Biosensors, Cell Dynamics Analysis, and Optogenetics Department of Cell & Developmental Biology and Department of Biochemistry & Molecular Biology, SUNY Upstate Medical University, Syracuse, New York.    The Departments of Cell & Developmental Biology and Biochemistry & Molecular Biology at SUNY Upstate Medical University in Syracuse, New York, are seeking cluster hires for two tenure-track faculty positions. The cluster hire program is aimed at attracting faculty who are developing new technologies in the areas of imaging, image analysis, cell dynamics analysis, biosensors for detecting disease biomarkers and point-of-care diagnostics, and photomanipulation/optogenetic approaches with potential applications to human health and disease. These Empire Innovation Scholars will complement additional junior faculty hires in the two departments as part of a coordinated expansion effort.

Candidates must have a PhD or equivalent degree in cell or molecular biology, biomedical engineering, biochemistry, physics, or a related field, and currently hold the rank of an assistant or associate professor or a comparable leadership position in private industry. Applicants should have established track records of funding and research productivity. Successful candidates are expected to develop and maintain a vigorous extramurally funded research program and participate in the education of medical and graduate students.   The successful candidates will join a thriving community of over 20 investigators with strengths in using intravital imaging and live-cell imaging to study cardiovascular development, pathogenesis of cancer and neurodegenerative diseases, development and regeneration of vision photoreceptors and immune disorders and development of biosensors and diagnostic assays. Academic appointment will be commensurate with experience and will carry the title of an Associate Professor of Empire Innovation or Professor of Empire Innovation. Preference will be given to candidates currently at the Assistant or Associate Professor level, or comparable rank in industry. 

This position is fully state-supported with a 12-month base salary, excellent health and retirement benefits, and competitive start-up funds. Our faculty are well supported by state-of-the-art imaging resources and outstanding institutional core facilities.      Located in central NY, Syracuse provides a diverse, dynamic, and affordable metropolitan environment with easy access to outstanding recreational opportunities of the Adirondack Mountains and the Finger Lakes. Proximity of SUNY Upstate to Syracuse University and SUNY ESF campuses fosters productive scientific interactions and unique collaborative funding opportunities.    Please apply online to job #82494 at https://bit.ly/UpstateEIP and upload a cover letter, a curriculum vitae, and a research statement (up to three pages) consisting of a summary of accomplishments and description of future plans. Letters of recommendation will be requested separately. 

Review of applications will start November 15, 2024 and continue until the positions are filled.

Further information about the Cell & Developmental Biology and Biochemistry & Molecular biology departments, including additional open positions, can be found at https://www.upstate.edu/cdb/ and https://www.upstate.edu/biochem/. Applicants will be considered for primary appointment in either department depending on fit, but applicants are encouraged to indicate their preference in the cover letter.

At SUNY Upstate Medical University we strive to promote a professional environment that encourages varied perspectives from faculty members with diverse life experiences. A respect for diversity is one of our core values. We are committed to recruiting and supporting a rich community of outstanding faculty, staff and students. We actively seek applications from women and members of underrepresented groups to contribute to the diversity of our university community in support of our teaching, research and clinical missions.

Job Description Summary Supports microscopy related research and teaching in the Microscopic Imaging Core of Wake Forest University Biology by assisting the Director of Microscopy.

Job Description Essential Functions:

• Trains new users and assists in utilization of microscopes and related equipment.
• Maintains microscopes and related equipment in a clean and highly operational state.
• Communicates an excitement about imaging-related science to new students and visitors.
• Facilitates scheduling of equipment use and related record keeping/reporting.
• Reports to and coordinates overall activities with the microscopy director.
• Assists the director in other microscopy facility related directives as assigned.
• Assists undergraduates, graduate students, and faculty with design and implementation of experimental protocols related to microscopy by understanding research goals and needs of individual facility users.

Additional Job Description Accountabilities:

• Responsible for own work.
• Provides training and assists in the supervision of graduate and undergraduate student researchers.
• Reports activities and problems to the facility director. Physical Requirements:
• Sedentary work primarily involving sitting/standing; communicating with others to exchange information; repeating motions that may include the wrists, hands, and/or fingers; and assessing the accuracy, neatness, and thoroughness of the work assigned. 
• Ability to travel 7 miles between Innovation Quarter and main Reynolda campus (university shuttle or personal car) Disclaimer: This position profile identifies the key responsibilities and expectations for performance. It cannot encompass all specific job tasks that an employee may be required to perform. Employees are required to follow any other job-related instructions and perform job-related duties as may be reasonably assigned by the employee’s supervisor.

We have funded postdoc positions available in the Carpenter-Singh lab in Cambridge MA USA (Broad Institute of Harvard and MIT), paying $70,000 (or more with years of experience post-PhD) with a flexible start date.

There are two projects: - Rapidly identifying disease phenotypes from rare disease variants, and drugs to reverse their impact (as part of the NIH IGVF Consortium https://www.youtube.com/watch?v=8RcsC4a2Ews&list=PLJG0u60zazOtRAwamVGhaJ6eGqh-HASvw&index=6) - Using Cell Painting, transcriptomics, and proteomics data to predict toxicity of drugs and agrochemicals (as part of the OASIS Consortium https://oasisconsortium.org)

Both projects will have copious data produced by this time next year!

Summary Elephas, a Madison, WI-based biotechnology start-up company, seeks a talented individual to join our team as a Software Engineer specializing in fluorescence microscopy, multi-photon or Optical Coherence Microscopy (OCM) microscopes for biological applications. Applicants should be comfortable in a fast-paced and collaborative environment. The successful candidate will be a skilled and experienced software engineer who will contribute to developing, optimizing, and validating Elephas’ cancer diagnostics platform.

Essential Duties and Responsibilities

• Develop and optimize image analysis, signal processing and visualization solutions for combining multi-photon, OCT/OCM, slide scanning, and widefield microscopes used in biological imaging.
• Collaborate with interdisciplinary teams to understand and translate system requirements into efficient and reliable software solutions.
• Analyze and troubleshoot system issues, provide technical support, and propose innovative solutions.
• May assist with control system development (novel development).
• Stay up-to-date with the latest advancements in imaging technologies, identifying opportunities for improvement and innovation.
• Follow a regulated software development methodology in an agile environment.
• Align with the Elephas values: Deliver patient-centric solutions, Deliver quality, Be science-driven, Be curious and innovative, Be generous and honest, and Be a good partner and teammate.

Education/Experience/Skills

• Master’s or PhD in Computer Science, Computer Engineering, Applied Mathematics or a similar field, or applicable industry experience.
• Strong experience with C++ and C, with a minimum of 5 years of experience.
• Proficiency in troubleshooting compile-time errors.
• Expertise in multiprocess communications.
• Experience in combining languages, such as using a C++ library in Python or Matlab.
• Proficiency in C# preferred.
• Strong graphics programming skills in DirectX, Vulcan, OpenGL, Metal, or similar.
• Experience with time-lapse animation or gaming interface and design is preferred.
• Proficiency in image analysis.
• Experience in high-performance computing.
• Experience coding in a team environment, including version control and code reviews.
• Proficiency with Linux, Windows, and Mac operating systems.
• Experience with Matlab, Octave, and R is preferred.
• Strong mathematical skills
• Strong problem-solving and analytical skills, with the ability to work independently and collaboratively in a dynamic team environment.
• Excellent communication skills and the ability to effectively present technical concepts to technical and non-technical stakeholders.   We offer our employees competitive compensation and benefits, including paid time off, health insurance, life insurance, flexible spending accounts, a 401(k) plan, and stock options. Relocation assistance is available. Qualified candidates should forward their resumes to mcostin@elephas.com or apply through the careers section on our website, https://elephas.com/join-elephas.

DISCLAIMER The preceding job description has been designed to indicate the general nature and level of work performed by employees within this classification. It is not designed to contain or be interpreted as a comprehensive inventory of all duties, responsibilities and qualifications required of employees assigned to the job.   We are an Equal Opportunity Employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity, status as a veteran, and basis of disability or any other federal, state or local protected class.

The Meyer lab (meyerlab.yale.edu) is part of the Department of Molecular, Cellular and Developmental Biology, and the Systems Biology Institute at Yale University. We seek to understand the molecular logic of cellular decision making in the context of embryonic development. We study mechanisms of gene regulation with a particular focus on the role of chromatin mechanics/biophysics in sensing, processing, and memorizing information. To this end, we synthetically control signaling nodes (optogenetics, synthetic biology tools) and combine this approach with imaging-based readouts to record information flow at molecular resolution (single molecule imaging). We are seeking a passionate, motivated, and open-minded postdoctoral researcher to join our team and help build a single-objective oblique plane light sheet microscope for single-molecule imaging. This project, supervised in collaboration with experts in the light sheet community, offers a unique opportunity to contribute to cutting-edge imaging technology and explore its applications to understand principles of gene regulation. Applicants must have a PhD and prior experience in microscopy/optics, physics, or related fields. To apply, please submit a cover letter outlining your motivation and include contact information for three references to kirstin.meyer@yale.edu. For more information, please see meyerlab.yale.edu.

The role will focus significantly on mesoSPIM microscope support, advanced image analysis, and data management. This position will work with the Director of the MDIBL Light Microscopy CORE Facility and interface significantly with Director of the MDIBL Comparative Genomics and Data Science (CGDS) Core.

Sous l’autorité hiérarchique de la cheffe des plateformes scientifiques, mais en supervision immédiate avec la responsable de la plateforme, en étroite collaboration avec les directeurs scientifiques, les tâches et responsabilités principales du spécialiste technique en microscopie seront :

• Agir à titre de personne-ressource auprès des chercheurs, du personnel de recherche et des étudiants pour les besoins en microscopie optique;
• Participer aux rencontres statutaires des opérations avec la responsable de la plateforme et la Cheffe des plateformes scientifiques ;
• Travailler en équipe avec le personnel de la plateforme;
• Participer à la formation des étudiants et personnel de recherche aux principes de la microscopie optique et à l'utilisation des différents appareils et logiciels d'analyses ;
• Collaborer avec la responsable de la plateforme à l’offre de service d’assistance et conseils aux étudiants, personnel de recherche et chercheurs pour les aspects scientifiques et techniques de leurs projets de recherche;
• Assurer l’inspection, la mise en marche des microscopes, la maintenance de routine et résoudre les problèmes techniques ;
• Accompagner les utilisateurs dans les tâches d'analyse d'images;
• Vérification et remplissage des fournitures de microscopie;
• Participer aux tâches administratives telles que la surveillance des journaux d'utilisation (logs), l'impression du matériel de formation, l'édition des rapports;
• Aide au développement continu du portail de réservation et de facturation en ligne.

Aptitudes et qualités requises

• Faire preuve d'autonomie et d'initiative;
• Débrouillardise et excellentes compétences dans la résolution de problème;
• Bonnes habilités interpersonnelles et excellent service à la clientèle;
• Capacité à gérer efficacement les priorités;
• Sens de l'organisation et gestion du temps;
• Maitrise du français écrit et parlé (anglais un atout) ;
• Attention au détail.  

The FIB-SEM Collaboration Core (F-SCC) at Yale School of Medicine is seeking a talented, skilled, and highly motivated researcher to assume the role of Senior Staff Scientist (90282BR). The candidate will play a leadership role in managing and performing electron microscopy (EM) sample preparation and FIB-SEM sample preparation operations. At the forefront of volume Electron Microscopy, the F-SCC utilizes the state of the art enhanced Focused Ion Beam Scanning Electron Microscopy (FIB-SEM) technology for large volume imaging with nanometer isotropic resolution. Under supervision of the Director, the candidate will be responsible for optimizing the existing electron microscopy (EM) sample preparation protocols of biological specimens, developing new methods for clinical specimens, and establishing an automated EM sample preparation pipeline. The candidate is expected to perform independent research, experiments, and laboratory techniques, and work closely with supervisor, group members, and collaborators.